The effect of Hemiacidrin, a new chemolytic agent for dissolution of urinary calculi, and ammonium chloride, used after tube cystostomy, was evaluated in twelve goats suffering from urethral obstruction with intact urinary bladder and urethra. Cystic irrigation of a 10% solution of ammonium chloride (n=6) (group A) and Hemiacidrin (n=6) (group B) was done and the treatments were compared and evaluated on the basis of clinicophysiological, haemato-biochemical parameters and urinalysis. Mild pain, swelling and exudation were recorded after tube cystostomy in both groups. No urine leakage was seen in any of the groups. The duration of initiation and free flow of urine was early in group B (3 to 7 days) than in group A (7 to 10 days). The catheter was removed (recovery) from 6 to 10 days in group B and 10 to 13 days in group A. The haematological parameters (Hb, PCV and TLC) did not show any significant change. The elevated biochemical parameters (BUN, creatinine, AST, and ALT) decreased early in group B than in group A. The alkaline pH of urine decreased early in group B than group A. The animals of group A became restless, showed vocalization, rigidity and salivation after ammonium chloride irrigation. Whereas the animals of group B remained normal after cystic irrigation with Hemiacidrin. The recovery rate was 66.67% in group A and 100% in group B. It was concluded that 10% Hemiacidrin was a better chemolytic agent for dissolution of urethral calculi than 10% ammonium chloride solution after their cystic irrigation in goats.
