In this investigation 42 cattle and buffaloes suspected for foreign body were selected to study the incidence, haematobiochemical changes and response to treatment. Highest incidence of foreign body seen was in 6–10 years of age. Maximum number of cases were of nondescript cattle and buffaloes. Buffaloes were affected more than cattle. Incidence in female animals was more. Penetrating metallic foreign body was a major etiological factor. Haematological observation showed increase in total leucocyte count and neutrophil count. Serum biochemical profile showed decreased calcium, glucose, total protein and increase phosphorus, urea, GOT and GPT levels. Ruminal fluid examination showed marked reduction in total protozoal count with low protozoal motility. Trypsin inhibitor assay positively diagnosed foreign body syndrome. Reliability of x-ray in detecting foreign body was 87%. Three groups were made and in group I (8 animals). Amoxicillin-Cloxacillin was given after rumenotomy. In group II (8 animals) ceftriaxone was given after rumenotomy. In group III (26 animals) only pericarditis cases were selected and streptopenicillin was given without surgery. In group I, all the animals recovered. In group II, seven out of eight animals showed recovery. In group III, all the animals died.
