Department of Surgery and Radiology, College of Veterinary and Animal Sciences, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana (Punjab).
*Corresponding author; E-mail: drraghupau@rediffmail.com.
The study was conducted on 37 clinical cases of canine mammary neoplasms (CMN) to evaluate the role of adjuvant chemotherapy for their management. Comparative evaluation of three different methods for the management of canine mammary neoplasms viz surgery alone (n=23), adjuvant chemotherapy (n=8), and chemotherapy alone (n=6) was carried out. Chest radiography, ultrasonography, hematology, blood biochemistry and histopathology were conducted to evaluate the tumor type. Malignant mammary neoplasms were treated by adjuvant chemotherapy using combination of doxorubicin and cyclophosphamide 25 mg/m2 i.v. and 30 mg/m2 P.O., respectively, for four consecutive days as a single cycle and four such cycles were given to each dog. Management of CMN by adjuvant chemotherapy was found to be more effective than other two methods, which resulted in 85.71% disease free survival rate. Because of the combination therapy, no side effects of either of the drugs were noticed.
Canine, Cyclophosphamide, Doxorubicin, Mammary neopasms
