1Department of Animal Husbandry, CCS Haryana Agricultural University, Hisar-125 004, (Haryana).
2Department of Veterinary Surgery and Radiology, College of Veterinary Sciences, CCS Haryana Agricultural University, Hisar-125 004, (Haryana).
3CCS Haryana Agricultural University, Hisar-125 004, (Haryana).
The study was conducted in 5 healthy goats. Midazolam was administered 0.4 mg/kg, i.v.. There were no significant changes in heart rate, blood pressure, central venous pressure and respiratory rate. Primary T-wave changes were observed at varying time intervals after midazolam administration. The depression of ST-segment was recorded in three animals up to 5 min. No significant variations in pH, PaCO2, HCO3 concentration was seen. Appreciable reduction in PaO2 and PvO2 values were observed after midazolam administration, which did not return to normal up to the end of the observation. The oxygen extraction ratio increased significantly from 5 min after and gradually increased to 52.95±1.50% at 30 min. There was no evidence of tissue hypoxia. No significant changes in hematological and blood biochemical parameters were recorded. Mean values of cardiovascular and respiratory parameters did not show significant changes. However, few animals showed appreciable decrease in heart rate and blood pressure, hypoxaemia and desaturation of haemoglobin.
Cardiopulmanary effects, goats, midazolam
