Effect of VP3 gene of chicken infectious anaemia virus and vincristine in the regression of canine transmissible venereal tumour

Sixteen dogs of either sex affected with canine transmissible venereal tumour (CTVT), equally divided in four groups, were treated with VP3 gene of chicken infectious anaemia virus (100 μg/kg b.wt, intratumourally, once a week) and vincristine (0.025 mg/kg b.wt, i.v. once a week) either alone or in combination, for four consecutive weeks. The efficacy of the treatment was assessed by determining the level of NK cells in peripheral blood. A gradual increase in the level of NK cells was observed after the initiation of the treatment. Its level was higher at second and third week of treatment. Its level was significantly higher in the animals treated with the combination of the VP3 gene and vincristine as compared to the animals treated with either of them alone.