Total intravenous anaesthesia (TIVA) with propofol in sheep: A clinical and haematobiochemical study

Changes during surgical interventions viz., placement of central venous catheters (group B), docking/tail amputation (group C), bilateral orchiectomy (group D) and no surgical stimuli as control (group A)} with propofol as TIVA were assessed in 24 apparently healthy male sheep. Each sheep was premedicated with glycopyrrolate (0.02 mg/kg b.wt, i.m.) and five min later anaesthesia was induced with propofol (4.00 mg/kg b.wt, i.v.). The clinical parameters included rectal temperature and respiratory rate, while haematobiochemical parameters included Hb, PCV, TEC, TLC, DLC, blood glucose, total serum protein and serum triglyceride. Rectal temperature and respiratory rate did not show any significant variability in any of the groups. Haemoglobin and PCV reduced nonsignificantly in all groups. TLC and DLC were found within physiological limits. Blood glucose decreased initially followed by an increase in three groups after propofol induction while the castration group exhibited a non-significant increase from very beginning. Total serum protein declined in all groups. A sudden increase in serum triglyceride (TG) was observed at one min post-propofol induction in all groups, which later on declined.