Effects of dexamethasone administration following thiopentone induced-circulatory insufficiency in buffalo calves

A study was undertaken to evaluate the effects of dexamethasone following thiopentone induced circulatory insufficiency in buffalo calves. Dilated pupils became constricted within 15 min and by 30 to 45 min resumption of corneal and palpebral reflex activity started after administration of dexamethasone. Electrical activity in the EEG began to appear between 40 seconds and 5 min. The MAP started increasing at 1.75±0.76 min of dexamethasone administration and values were further stable at 3.17±0.77 min and near base values at 45 min. No significant change in the HR was seen. Central venous pressure, though lowered after dexamethasone administration, remained higher than base values until 45 min. Arterial oxygen tension remained elevated throughout the period of study, while venous O₂ and arterial CO₂ tension were within normal limits. There was a slight drop in rectal temperature. There was a significant hyperglycaemia after dexamethasone administration whereas, the other blood biochemical parameters were not affected. The super physiologic doses of dexamethasone can be a valuable adjunct to the therapy in combating circulatory insufficiency due to excessive doses of thiopentone.