Physiological and biochemical effects of buprenorphine and carprofen administered to manage postoperative pain in dogs

The present study was undertaken to evaluate physiological and biochemical effects of buprenorphine and carprofen given to manage the postoperative pain in dogs. 12 clinical cases of dogs presented for elective abdominal surgery were included. Inj. buprenorphine was given 0.01 mg/kg b.wt, i.m. 60 min before surgery and then repeated at every 12 hr up to 48 hr and tab. carprofen was given 4 mg/kg b.wt orally 60 min before surgery and then repeated at every 8 hr up to 48 hr. The physiological and biochemical parameters were analysed preoperatively, after recovery, and at 8, 24 and 48 hr postoperatively. The respiratory and heart rates increased significantly and temperature decreased non-significantly after recovery in both groups. Serum glucose and cortisol significantly increased at immediate post-recovery stage as compared to its preoperative value in both groups. BUN and serum creatinine showed a non-significant change in both groups.