1MVSc Scholar, Nanaji Deshmukh Veterinary Science University, Jabalpur, MP
2Associate Professor, Nanaji Deshmukh Veterinary Science University, Jabalpur, MP
3Assistant Professor, Nanaji Deshmukh Veterinary Science University, Jabalpur, MP
4Professor and Head, Nanaji Deshmukh Veterinary Science University, Jabalpur, MP
5Professor, Department of Veterinary Surgery and Radiology, College of Veterinary Science and Animal Husbandry, Nanaji Deshmukh Veterinary Science University, Jabalpur, MP
*Corresponding author; E-mail: aprashahi12@rediffmail.com
Online published on 17 December, 2015.
The study was conducted on 20 adult dogs of either sex, suffering from malignant cutaneous tumours. All the dogs were divided randomly in to two equal groups. Group I received a combination of 5-Fluorouracil (150 mg/m2 BSA) and Cyclophosphamide (100 mg/m2 BSA) which were administered i.v. simultaneously on 10th day postoperatively, repeated for four consecutive weeks. In Group II, adjuvant chemotherapy of Doxorubicin and Cyclophosphamide was administered on 10th postoperative day using the following schedule: Doxorubicin, i.v. at 30 mg/m2 once weekly, for 3 consecutive weeks; Cyclophosphamide, i.v. at 100 mg/m2, 3 days after Doxorubicin administration, for 3 consecutive weeks. In conclusion, it can be suggested that the combination of surgical intervention along with chemotherapy using combination of Cyclophosphamide and Doxorubicin may be effective to check the recurrence of tumour and its metastasis.
Adjuvant Chemotherapy, Cutaneous tumor, Dogs
