Clinical, anaesthetic and biochemical effects of Lycopersicum esculentum (Tomato) as a preanaesthetic to propofol anaesthesia in dogs

The study was conducted to evaluate clinical, anaesthetic and biochemical effects of Lycopersicum esculentum as a preanaesthetic to propofol anaesthesia in dogs. Twelve healthy male dogs were randomly divided into two equal groups; group I animals received propofol ‘to effect’ intravenously, whereas group II animals were administered with alcoholic extract of Lycopersicum esculentum leaves 100 mg/kg b.wt intraperitoneally 30 min prior to intravenous administration of propofol. A significant increase in the heart rate and respiratory rate was recorded at the initial intervals in both groups. The duration of action was longer in the animals of group II as compared to the animals of group I. The animals of group I recovered quickly with an average standing time of 25.67±0.71 min and ambulation time of 27.33±1.78 min; whereas in the animals of group II, the recovery time was longer and an average ambulation time was 41.50±7.49 min. The dose of propofol required to produce anaesthesia was 6.54±0.33 mg/kg b.wt and 5.88±0.16 mg/kg b.wt in the animals of groups I and II, respectively. Vomition was a consistent finding in group II animals. Serum glucose, ALT and creatinine in both groups was within normal physiological range. It was concluded that Lycopersicum esculentum as a preanaesthetic decreases the anaesthetic dose of propofol, and produces longer duration of anaesthesia, but the occurrence of vomition may limit its use as a preanaesthetic.