Evaluation of halothane, isoflurane and sevoflurane in dogs premedicated with glycopyrrolate-xylazine and anaesthetised with ketamine-diazepam: haemato-biochemical study

Present study was conducted on 18 clinical cases of dogs to evaluate the effect of halothane, isoflurane or sevoflurane inhalation anaesthetic agents on haemato-biochemical parameters. The dogs were randomly divided into three groups, A, B and C with six animals in each group. All the animals of three groups received glycopyrrolate (0.01 mg/kg b.wt) and 10 min later xylazine (0.5 mg/kg b.wt) intramuscularly as preanaesthetic medication. After 10 min of the administration of preanaesthetics, anaesthesia was induced by administering diazepam (0.25 mg/kg b.wt) and ketamine (5.0 mg/kg b.wt) intravenously till effect. Anaesthesia was maintained in animals of groups A, B, C with halothane, isoflurane or sevoflurane, respectively in 100% oxygen. The haematological (Hb, PCV, TLC, DLC) and biochemical (glucose, urea, creatinine, ALT, AST) parameters were estimated at different time intervals to evaluate the effects of inhalation anaesthetic agents used. The results indicated that the effect of sevofurane on haemato-biochemical parameters was the least in comparison to halothane and isoflurane.