Evaluation of propofol and ketofol as induction agents in dogs premedicated with butorphanol-diazepam for isoflurane anaesthesia

The objective of the study was to compare the effects of propofol and ketofol as anaesthetic induction agents in dogs premedicated with diazepam for isoflurane anaesthesia. Twelve dogs used in the study in two equal groups, were premedicated with butorphanol (0.2 mg/kg b.wt, i.m.) and diazepam (0.5 mg/kg b.wt, i.v.). After 5 min, general anaesthesia was induced in animals of group 1 with ketofol (ketamine and propofol mixture 1:1) and with propofol in group 2. In both groups, anaesthesia was maintained on isoflurane. The induction dose of ketofol was significantly lower than propofol. Uniform and pronounced muscle relaxation along with steady pattern of sedation was observed in ketofol group. All haematobiochemical parameters remained within normal range during anaesthesia in both groups. In conclusion, ketofol can be considered as a more suitable anaesthetic induction agent than propofol for the routine surgical procedures in dogs.