Evaluation of propofol CRI in dogs premedicated with atropine sulphatebutorphanol-diazepam/midazolam

The present study was conducted on 12 dogs, presented for surgical intervention, which were randomly divided into two groups of six dogs each. All the dogs were premedicated with atropine (0.02mg/ kg body wt) and butorphanol (0.2mg/kg, body wt) intramuscularly. After 15 min, diazepam (0.5mg/kg body wt) and midazolam (0.2mg/kg body wt) were administered intravenously in group I and II, respectively. In both groups, the anaesthesia was induced by intravenous administration of 1% propofol till effect and maintained on1% propofol (0.4mg/kg/ min CRI up to 50 min). Potent dose sparing effect was exhibited by the preanaesthetics on the induction dose of propofol. Sedation quality was good to excellent with smooth induction and rapid recovery without any major complication. Both the combinations produced adequate analgesia, muscle relaxation and sufficient anaesthetic depth to perform surgery. All clinico-physiological and haemato-biochemical parameters stayed within normal physiological limits and did not show any significant difference between the groups though they varied significantly within the groups at various intervals.