1PhD Scholar, Division of Veterinary Medicine, Indian Veterinary Research Institute, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly-243 122 (Uttar Pradesh)
2MVSc Scholar, Division of Veterinary Medicine, Indian Veterinary Research Institute, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly-243 122 (Uttar Pradesh)
3Senior Scientist, Division of Veterinary Medicine, Indian Veterinary Research Institute, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly-243 122 (Uttar Pradesh)
4Principal Scientist, Division of Veterinary Medicine, Indian Veterinary Research Institute, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly-243 122 (Uttar Pradesh)
*Corresponding author; E-mail: sahadeb.csmlab@gmail.com
Online published on 16 June, 2025.
The current study was conducted at calf section of Cattle and buffalo Farm under the LPM Division of IVRI with the main objective to understand the oxidant-antioxidant imbalances along with changes in HR, RR, temperature, TLC, TP, LDH and their mitigation using ascorbic acid as an adjunct in calves affected with septic arthritis presented with the history of inappetence, fever, pain and local swelling at the joint. Overall incidence was reported to be 2.94%, which was highest in Vrindavani calves. To determine the oxidant-antioxidant imbalance, glutathione and lipid peroxides levels were measured, which were found to be elevated in diseased animals indicating the oxidative cell injury in arthritis. Treatment regimen adopted including administration of antibiotic and anti-inflammatory drugs, antiseptic dressing along with ascorbic acid (an antioxidant) brought earlier improvement showing that correction of oxidative stress during the course of therapy is essential for faster clinical recovery. Effect of therapy was also reflected in the composition of synovial fluid in calves receiving antioxidant as an adjunct therapy.
Arthritis, Ascorbic acid, Calves, Oxidative and nitrosative stress, Sepsis
