Indian Journal of Veterinary Surgery
  • Year: 2024
  • Volume: 45
  • Issue: 2

Therapeutic management of appendicular osteoarthritis in dogs using platelet rich plasma (PRP) and pentosan polysulphate sodium

  • Author:
  • Nitesh Suryavanshi1, Randhir Singh2,*, Shobha Jawre3, Yamini Verma4, Rakesh Kumar Barhaiya5, Apoorva Mishra6, Babita Das7, Apra Shahi8
  • Total Page Count: 12
  • Page Number: 91 to 102

1MVSc Scholar, Veterinary Anatomy, College of Veterinary Science and Animal Husbandry, Nanaji Deshmukh Veterinary Science University, Jabalpur- 482 001 (Madhya Pradesh)

2Associate professor, Veterinary Anatomy, College of Veterinary Science and Animal Husbandry, Nanaji Deshmukh Veterinary Science University, Jabalpur- 482 001 (Madhya Pradesh)

3Professor, Veterinary Anatomy, College of Veterinary Science and Animal Husbandry, Nanaji Deshmukh Veterinary Science University, Jabalpur- 482 001 (Madhya Pradesh)

4Professor and Head, Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Nanaji Deshmukh Veterinary Science University, Jabalpur- 482 001 (Madhya Pradesh)

5Assistant Professor, Veterinary Anatomy, College of Veterinary Science and Animal Husbandry, Nanaji Deshmukh Veterinary Science University, Jabalpur- 482 001 (Madhya Pradesh)

6Assistant Professor, Veterinary Anatomy, College of Veterinary Science and Animal Husbandry, Nanaji Deshmukh Veterinary Science University, Jabalpur- 482 001 (Madhya Pradesh)

7Associate professor, Veterinary Anatomy, College of Veterinary Science and Animal Husbandry, Nanaji Deshmukh Veterinary Science University, Jabalpur- 482 001 (Madhya Pradesh)

8Professor and Head, Department of Veterinary Surgery and Radiology, College of Veterinary Science and Animal Husbandry, Nanaji Deshmukh Veterinary Science University, Jabalpur- 482 001 (Madhya Pradesh)

*Corresponding author; E-mail: randhirvet2k@gmail.com

Online published on 13 October, 2025.

Abstract

The present study was conducted on 12 dogs suffering from appendicular joint osteoarthritis (OA) presented at Veterinary Clinical Complex, Jabalpur during the study period of six months. The dogs were equally distributed into three treatment groups. In group I, the dogs were treated with inj. carprofen 4 mg/kg body wt, s.c. for 5 days and tab. glucosamine hydrochloride 500 mg, chondroitin sulphate 400 mg, manganese sulphate 5 mg, Boswellia serrata 50 mg, Withania somnifera 50 mg, Vitamin C 12.5 mg orally for 30 days. The dogs of group II were treated as in group I with addition of an intra-articular injection of 1 mL platelet-rich plasma (PRP) on days 0, 7, 14, 28 and 45. The dogs of group III were treated as in group I with addition of an intraarticular injection of 1 mL PRP and pentosan polysulfate sodium 3 mg/kg body wt, s.c. on days 0, 7, 14, 28 and 45. The results indicated that both the treatment regimens (group II and III) were equally effective in reducing osteoarthritic pain; however, significant (P<0.05) decrease in lameness and pain bearing scores were earlier in group III as compared to group II.

Keywords

Dog, Osteoarthritis, Pentosan polysulfate sodium, Platelet rich plasma