1Lecturer, BS Anangpuria Institute of Pharmacy, Faridabad, Haryana, India
2Professor, School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India
3Professor and Principal, BS Anangpuria Institute of Pharmacy, Faridabad, Haryana, India
4Associate Professor, School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India
5Professor, Department of Pharmaceutics, Jamia Hamdard University, Delhi, India
*Corresponding author Email id: avneetkaur.lamba@gmail.com
Online published on 12 April, 2016.
Enhancement of the solubility and dissolution of Telmisartan using solid dispersion (SD) with PVP K-90, PVP K-30 and Eudragit RS-100 by a solvent evaporation technique. In this method, SDs were prepared by the solvent evaporation method using minimum quantity of ethanol. Infrared (IR) spectroscopy was performed to identify physio-chemical interaction between the drug and the polymers, and differential scanning calorimetry (DSC) was performed to identify the melting point of SDs and their effect on dissolution behaviour. Morphology of the SDs was studied using scanning electron microscopy (SEM) and powdered X-ray diffractometry (PXRD). A comparative evaluation of the dissolution of Telmisartan SDs, pure drug and marketed formulation (tablet) was carried out. In the Results section, dissolution of Telmisartan significantly improved in SDs as compared to the pure drug. Telmisartan exhibited better aqueous solubility in the presence of all the polymers used. IR spectroscopy and DSC showed no change in the crystal structure of Telmisartan. It was concluded that SD prepared by the solvent evaporation method can be successfully used for the improvement of dissolution of Telmisartan.
Solid dispersions, Telmisartan, PVP K-30, PVP K-90, Eudragit RS-100, Solvent evaporation
