1Department of Chemical Engineering, National Institute of Technology, Raipur, Raipur, (CG), India, Email id: sonaligores@gmail.com
2Department of Chemical Engineering, National Institute of Technology, Raipur, Raipur, (CG), India, bmazumdar.che@nitrr.ac.in
3Department of Bio Medical Engineering, National Institute of Technology, Raipur, Raipur, (CG), India, arinbit.bme@nitrr.ac.in
Online published on 2 August, 2016.
Capillary dysfunction is an outcome of chronic non-communicable diseases like diabetic, cancer, acute stroke, tumor hypoxia etc. In case of human beings, capillary flow disturbance alters the oxygen transport in tissues and is a source of hypoxia. Therefore, early detection of the above phenomenon in capillaries may prevent the progress of the disease. But the traditional practice is associated with coupling of antigen-antibodies in smaller confinement of blood which is an invasive technique as well. It leads to the assessment of RBCs flowing through microcapillaries at in vitro condition by analytical and numerical modeling. In this paper an exhaustive review is presented for the above issue. Lastly authors proposed an ideal model by addressing limitation issues discussed in previous studies.
Rheology, Capillary dysfunction, Microchannels, Hypoxia, Non-communicable diseases
