INROADS- An International Journal of Jaipur National University
  • Year: 2017
  • Volume: 6
  • Issue: 2

Green protocol for sp-sp2 coupling of aryl iodide and alkynes using copper carbonate: Facile synthesis of aryl alkynes

1Research Scholar, Department of Chemistry, School of Basic and Applied Sciences, Galgotias University, Greater Noida-201308, Uttar Pradesh, India

2Professor, Department of Chemistry, School of Basic and Applied Sciences, Galgotias University, Greater Noida-201308, Uttar Pradesh, India

3Professor, Department of Chemistry, Jamia Millia Islamia, New Delhi, India

*Corresponding author email id: jain1dcy@gmail.com

Online published on 31 August, 2018.

Abstract

Iodoarenes are cross coupled with terminal alkynes and arynes in presence of copper carbonate in Dimethyl fomamide at 125°C to offered substituted alkynes in good-to-moderate yield. The reaction features the use of CuCO3 which act as efficient base as well as catalyst to promote the reaction. The newly developed protocol has been successfully employed for the synthesis of substituted internal alkynes.

Keywords

Copper, Copper carbonate, C-C coupling, Copper coupling, sp-sp2 coupling, Cu catalysed, Internal alkynes