1Hospital Superitendent, Teaching Veterinary Clinical Complex
2Assistant Professor, Department of Vet. Physiology and Biochemistry
3Assistant Professor
4Professor
Department of Medicine, Bombay Veterinary College, Maharashtra Animal and Fishery Sciences University Parel, Mumbai-400012 (Maharashtra)
*Corresponding Author email: drvksingh1981@gmail.com
Online published on 31 August, 2012.
The dog having history of anorexia, vomition, fever, icteric mucous membranes and delayed blood clotting was reported. The hemato-biochemical profile showed PCV 45.2%, TEC 6.52/cumm, TLC 25.2/cumm and Platelets 1,11,000/cumm. SGPT 351 IU/L, SGOT 108 IU/L, Direct Bilirubin 9.1 mg/dl, Indirect Bilirubin 4.2 mg/dl, Direct Bilirubin: Indirect Bilirubin ratio 2.17, Creatinine 1.8 mg/dl, BUN 28.8 mg/dl. Scintigraphy with 99mTc-Mebrofenin revealed 1.86% clearance/hour suggestive of unsatisfactory hepatobiliary clearance due to intra-hepatobiliary obstruction. Interventional approach with Phenobarbitone @ 0.5mg/kg body weight for microsomal enzyme activation and dietary stimulation was incorporated (fatty diet) to facilitate biliary clearance.
Biliary clearance, Canine, Hepatic obstruction, Scintigraphy, Mebrofenin
