1Division of Surgery Indian Veterinary Research Institute Izatnagar-243122, India.
2Division of Pharmacology and Toxicology
3Division of Pathology.
*Corresponding author: Tel: +91-581-2302870; Fax: +91-581-2303284; E-mail: maiti@ivri.up.nic.in
To evaluate the efficacy of the herb, Cissus quadrangularis Linn as an adjunct to internal fixation in bone healing in dogs, unilateral comminuted diaphyseal femoral osteotomy was created under general anaesthesia and immobilized with neutralization bone plate. All animals received routine postoperative treatment. In group B, additionally ethanolic extract of the herb was applied on skin surface twice a day along with subcutaneous injection (50 mg/kg body wt) on every alternate day for 20 days postoperatively. Early resolution of inflammatory signs and weight bearing were observed in animals of group B. Accelerated bone healing with complete bridging of comminuted fragments, extensive bony deposition along with periosteal and medullary continuity across the osteotomies site in the animals of group B were observed. Whereas, the process was relatively slow and the union was incomplete on day 60 in the animals of group A (control). It is concluded that Cissus quadrangularis accelerated the fracture healing.
Herb, Cissus quadrangularis, dog, osteotomies healing, femur, radiography, scanning electron microscopy, histopathology.
