1Department of Urology, Faghihi Hospital Shiraz University of Medical Sciences 71345-1744, Shiraz, Iran.
2Department of Urology, Jahrom College of Medical Sciences, Jahrom, Iran.
3Department of Pharmaceutics, School of Pharmacy.
4Department of Pathology, School of Medicine.
5Department of Pharmacology, School of Medicine.
6Gastroenterohepatology Research Centre, Nemazee Hospital, Shiraz University of Medical Sciences, 71345-1744, Shiraz, Iran.
*For correspondence: Tel: +98 791 226706; Fax: +98 791 2262004; E-Mail: hassanpour74@yahoo.com.
To evaluate the safety of using captopril gel as an antifibrotic agent for preventing recurrence of urethral stricture after a direct vision internal urethrotomy, twelve rabbits were divided into three equal groups, and three types of gel were instilled into the urethra using a lubricating gel as placebo (group I), 0.1% captopril gel (group II), and 2.5% captopril gel (group III). One more rabbit served as control. Changes in the urethral mucosa were evaluated at the end of one week and three months. Mild ulceration and denudation of proximal and distal urothelium were seen with secondary aggregation of inflammatory cells beneath the lamina propria in the early phase in all three groups. No inflammation, scarring, or other side effects were seen in the late phase. As the local side effects of captopril gel on the urothelium were not significant its application in human urethral stricture is recommended.
Captopril gel, urethra, rabbit, side effect
