Effect of Experimental Distal Ileal Obstruction on Clinical, Hematological, Serum and Urine Biochemical Parameters in Sheep

To determine clinical and paraclinical changes in blood and urine following experimental distal ileal obstruction in sheep, 7 Iranian crossbred male sheep (2–2.5 years, 45–50 kg) were used. A polyethylene tube reinforced with braided cotton tape was surgically placed around the ileum 8 to 10 cm cranial to the ileocecal valve one week prior to the experiments. Both ends of the tube were brought out through the opening in abdominal wall, which were tightened on day 0. Observations were recorded for 6 days. At the end of experiment the animals became lethargic, anorexic, weak and dehydrated. There was a significant (P<0.05) increase in temperature, respiratory and heart rate as well as in hematocrit, total protein, RBC and WBC counts. Metabolic acidosis was seen in experimental sheep. Significant increases (P<0.05) were detectable in serum concentrations of urea nitrogen and creatinine. There was a significant decrease (P<0.05) in urinary concentrations of urea nitrogen and creatinine as well as in urinary pH. In conclusion, distal ileal obstruction in sheep leads to dehydration, tachypnea, tachycardia, azotemia and metabolic acidosis.