1Department of Biochemistry, Faculty of Veterinary Medicine University of Kafkas, Pasacayiri 36040 Kars, Turkey.
2Department of Internal Medicine, Faculty of Veterinary Medicine University of Kafkas, Pasacayiri 36040 Kars, Turkey.
†The research work has been carried out with the approval of the Institutional Ethics Committee of Kafkas University, Faculty of Veterinary Medicine.
To investigate the ameliorative effect ofL- carnitine on phenylhydrazine induced oxidative damage to liver, kidney and spleen, twenty-eight Swiss albino mice were divided into four groups and injected 0.9% NaCl (control), 40 mg/kg/day phenylhydrazine, phenylhydrazine+L-carnitine or 1000 mg/kg/day L-carnitine. Malondialdehyde (MDA) level was found to be significantly (P<0.001) lower in phenylhydrazine+L-carnitine group compared to the phenylhydrazine group in all tissues. Reduced kidney glutathione (GSH) level in phenylhydrazine given group was restored to normal by L-carnitine. However, increased uric acid level by phenylhydrazine was not decreased by L-carnitine administration. It appears that L-carnitine may prevent tissue damage and lipid peroxidation induced by phenylhydrazine.
Phenylhydrazine, L-carnitine, mice, reduced glutathione, malondialdehyde, uric acid
