To study the effect of patulin, male mice were administered patulin orally once daily (0.1mg/kg bw). Patulin showed a significant increase in ALT and AST after 3 weeks. Also patulin showed highly significant increase in plasma level of ALP and LDH after 2 and 3 weeks, while LPO and total antioxidants showed highly significant increase for 2 week only and non significant in first and third weeks compared to the control. Histopathological changes coincided with biochemical changes observed in these experiments. The results of this study suggested that patulin affects liver function and the effect depended on time of exposure.
Patulin, liver function, mice
