1Department of Orthopaedic Surgery, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
2Department of Pathology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
3Organ Transplant Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
4Gastroenterohepatology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
*Corresponding author: Tel: +98-711-6474263; Fax: +98-711-6474263; E-mail: mehrabad@sums.ac.ir
To determine the healing effect of sodium fluoride on experimentally induced transverse midshaft radial fracture, 60 (3 mo) healthy, white rabbits (Oryctolagus cuniculus) were divided into 6 groups including four-case groups (A, B, C and D) and two-controls (E and F). Sodium fluoride (5 mg/kg/d for groups A and C and 10 mg/kg/d for groups B and D) was administered to the case groups from the first day postoperation. Groups A, B and E were euthanized at the end of the second week and groups C, D and F at the end of the sixth week. There was a significant difference in cortical bone regeneration thickness between B, E and C, F groups. In groups A, B and E there was a significant difference in the thickness of regenerated trabecular bone. The radiological scores showed gradual movement toward union. So, sodium fluoride can stimulate osteogenesis in periosteal and central osteoblasts in fractures.
Sodium fluoride, fracture, healing, rabbit
