1Department of Surgery School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
2Gastroenterohepatology Research Center, Department of Pathology, Nemazee Hospital.
3Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
4Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
5Stem Cell and Transgenic Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
*For correspondence: Tel: #98-711-6474263;Fax: 98-711-6474263; E-mail: mehrabad@sums.ac.ir.
To determine the effect of Plantago major on healing of burn wounds, 100 male Sprague-Dawley 180220 g rats were randomly divided into 4 groups. Groups of A, B and C each comprised of 30 rats, which were treated with silver sulfadiazine, 20% and 50% Plantago major solution. Group D comprised of 10 rats, which were considered as control group and were treated with Oserin. After 7, 14 and 21 d of treatment, the animals were sacrificed, burn areas were examined histopathologically and scored. There was no significant difference between groups on d 7 and 14 but the difference was significant on d 21. The best results were noticed in group C receiving 50% P. major solution. So Plantago major may be a suitable substitute for silver sulfadiazine especially when applied in 50% concentration.
Silver sulfadiazine, Plantago major, wound, healing, epithelialization, rat
