Journal of Applied Animal Research
  • Year: 2010
  • Volume: 38
  • Issue: 1

Pharmacokinetics and Residual Studies of Florfenicol Following Multiple Dose Oral Administration in Poultry

  • Author:
  • M. Lohani, A.H. Ahmad, K.P. Singh, Sheetal Verma
  • Total Page Count: 4
  • Page Number: 9 to 12

Department of Pharmacology and Toxicology, College of Veterinary and Animal Sciences, G.B. Pant University of Agriculture and Technology, Pantnagar-263 145, India

*For correspondence: Fax: +91-5944-233473; E-mail: ahahmad_2000@yahoo.com

Abstract

Pharmacokinetics of Florfenicol was established in the plasma of poultry. Florfenicol was given as multiple dose 30 mg.kg−1 orally daily for 5 days in poultry. The mean values of half-life,body clearance (ClB) and mean volume of distribution (Vdarea) were 8.39 and 7.91 h; 0.5 and 0.29 l.h−1.kg−1 and 4.8 and 2.70 l.kg−1 after first and last dose, respectively. On the basis of depletion study for Florfenicol in poultry, a withdrawal time of 72 h was calculated.

Keywords

Pharmacokinetics, residual, florfenicol, poultry, oral