Journal of Applied Biology and Biotechnology

Open Access
SCOPUSWeb of Science
  • Year: 2025
  • Volume: 13
  • Issue: 6

A recent review on the traditional use, phytochemical constituents, and pharmacological activity of Vitis vinifera L. (Vitaceae)

  • Author:
  • José Gilberto Gavídia Valencia1, Edmundo Arturo Venegas Casanova2, Zsanett Hajdu3, Gladys Silvia Gonzáles Pósito1, Carlos Naval Sopán Benaute2, Ruben Jesus Aro Díaz2, Keila Alina Castro Gálvez1, Luisa Olivia Amaya Lau4, Francisco Tito Cerna Reyes1, Roger Antonio Rengifo Penadillos1, Felipe Rubén Rubio López1, Ricardo Diego Duarte Galhardo De Albuquerque2,*
  • Total Page Count: 16
  • Published Online: Jan 8, 2026
  • Page Number: 5 to 20

1Department of Biochemistry, Faculty of Pharmacy and Biochemistry, National University of Trujillo, Trujillo, La Libertad, Peru

2Department of Pharmacotechnics, Faculty of Pharmacy and Biochemistry, National University of Trujillo, Trujillo, La Libertad, Peru

3University of Szeged, Szeged, Csongrád-Csanád, Hungary

4Department of Pharmacology, Faculty of Pharmacy and Biochemistry, National University of Trujillo, Trujillo, La Libertad, Peru

Abstract

Vitis vinifera link (Vitaceae) has been traditionally employed for the treatment of pain conditions, including abdominal and dental pain, as well as for its antibacterial and anti-inflammatory properties. This review aims to compile and analyze existing data regarding the traditional applications, phytochemical constituents, and pharmacological activities of V. vinifera. A comprehensive literature search was conducted in the Scopus and ScienceDirect databases, resulting in the selection of 93 relevant publications from the period 2017 to 2024. Among the identified bioactive constituents, proanthocyanidins and phenolic compounds have been recognized as major contributors to the plant’s pharmacological effects, which include anti-inflammatory, antioxidant, neuroprotective (particularly in cognitive disorders), and anticancer activities. The analgesic and antibacterial effects of V. vinifera have been substantiated through both in vitro and in vivo experimental models, primarily attributed to its phenolic content. Furthermore, the development of techniques that promote the strategic production of specific grape compounds is proposed as an alternative practice to mitigate the impacts of climate change on the chemical composition of grapevines.

Keywords

Phenolic Compounds, Flavonoids, Procyanidins, Proanthocyanidins, Grape, Pain Relief, Anti-Inflammatory