Circulative oxidative stress indices and ameliorative potential of S-adenosyl methionine in canine sarcoptes infestation

Present study describes the rhythm of oxidant/antioxidant status of dogs affected with sarcoptic mange and ameliorative effects of antioxidant (S-Adenosyl Methionine) supplementation on oxidant/antioxidant status of dogs affected with sarcoptic mange. Study was undertaken on twelve client owned dogs presented at TVCC, DUVASU, Mathura, confirmed to be suffering from sarcoptic mange, which were randomly divided in two groups (group 1 and 2) irrespective of age, sex and breed, comprising of six dogs each, while six healthy dogs were taken as control. Group 1 dogs were treated with only Doramectin @ 0.4 mg/kg body weight subcutaneous weekly for 5 treatments along with standard treatment of pyoderma, whereas group 2 were additionally given S-adenosylmethionine (SAMe) @ 20 mg/kg body weight orally for 28 days. In the present investigation dogs with sarcoptic mange were found in a state of oxidative stress as indicated by significantly elevated Total Oxidant Status (TOS) and Oxidative Stress Index (OSI) values and significantly reduced Total Antioxidant Capacity (T-AOC) values as compared to healthy dogs. The dogs of group 2 showed better clinical recovery and marked ameliorations in TOS, T-AOC and OSI values in comparison to group 1 at the end of therapy. On the basis of findings of present investigation, it is concluded that administration of SAMe in addition to standard therapy can mitigate these alterations expediting the clinical recovery of diseased dogs and therefore can be recommended as an adjunct therapy with miticides for management of canine sarcoptic mange.

HIGHLIGHTS

Significantly elevated total oxidant status and oxidative stress index and significantly reduced total antioxidant capacity values.

Administration of S-adenosylmethionine in addition to standard therapy can be recommended as an adjunct therapy in canine sarcoptic mange.