1Department of Veterinary Surgery and Radiology, College of Veterinary Science and Animal Husbandary, Nanaji Deshmukh Veterinary Science University, Jabalpur, M.P., India
2Department of Veterinary Microbiology, College of Veterinary Science and Animal Husbandary, Nanaji Deshmukh Veterinary Science University, Jabalpur, M.P., India
*Corresponding author: A Mishra; E-mail: mishra.ap07@gmail.com
Online Published on 21 September, 2022.
Melting ulcer, moderate and severe aggressive ulcerative keratitis pose a threat for staphyloma formation, perforations and blindness. The only resort to correct such condition remains corneal transplantation. Due to various shortcoming of transplantation procedure the present pilot trial was conducted to evaluate efficacy of platelet concentrates in such conditions. Platelet rich plasma drop was prepared and 1-2 drops were instilled 4 times/day for 15- 30 days in affected eye. This treatment group was compared with application of Leucocyte Platelet Rich Fibrin membrane which placed over the corneal ulcer and affixed with conjunctiva under general anesthesia. It was found that homologous PRP drops served the purpose of healing of moderate or grade II corneal ulcer satisfactorily; moreover, it prevented their advancement to severe or aggressive form. On the other hand, homologous L-PRF membrane provided sufficient scaffold for sealing of severe or grade III corneal ulcers with or without perforations and staphylomas.
• Successful healing of aggressive ulcerative keratitis using platelet concentrates
• Antimicrobial activity of platelet concentrates
Melting ulcers, Aggressive ulcerative keratitis, Platelet Rich Plasma, Leucocyte Platelet Rich Fibrin and dogs
