Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, P.V. Narsmiha Rao Telangana Veterinary University, Rajendranagar, Hyderabad, Telangana, India
*Corresponding author: K Sneha; E-mail: snehareddy1802@gmail.com
Online Published on 22 September, 2022.
Toxic effects of cisplatin (CP) and protective role of Terminalia arjuna (TA) and taurine were assessed on hepatic biomarkers using a total of 36 male Wistar albino rats that were grouped randomly into six groups (n=6). Group 1 acted as normal control. Groups 2, 5 and 6 were treated with CP @ 5 mg/kg b.wt, intraperitoneally on day 1 for cisplatin exposure. Thereafter, groups 3 and 5 were treated with TA @ 400 mg/kg b.wt. and groups 4, 6 with taurine @ 1000 mg/kg b.wt. orally for 14 days. Later rats were euthanized for histopathology of liver. Serum ALT was significantly (P < 0.05) increased in group 2. The tissue enzyme assays revealed a significant (P < 0.05) increase in TBARS and protein carbonyls and significant (P < 0.05) decrease in GSH in group 2 as compared to other groups. The concentration of cytokines showed a significant (P < 0.05) increase in TNF-alpha and IL-10 in group 2 when compared with group 1. Sections of liver tissue showed marked changes i.e., central vein dilation with oedema, congestion and degenerative changes with pyknotic and condensed nuclei in few hepatocytes. The groups 5 and 6 treated with respective dose of TA and taurine showed mild to moderate improvement in all the parameters in comparison to group 2. It is concluded that supplementation of Terminalia arjuna and taurine was found beneficial in countering the toxic effects of cisplatin on liver.
• Terminalia arjuna offers protection, have hepato-protective activity due to free radical scavenging and antioxidant property.
• Taurine has been shown to prevent cisplatin-mediated hepatic injuries by decreasing oxidative stress.
Cisplatin, Hepatotoxicity, Taurine, Terminalia arjuna
