1ICAR-National Dairy Research Institute, Karnal, Haryana, India
2Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana, India
3ICAR-Indian Veterinary Research Institute, Izatnagar, U.P., India
4Government Medical College, Haldwani, Uttarakhand, India
5Veterinary College, Bidar, KVAFSU, Karnataka, India
Cow’s milk allergy is a common diagnosis in infants and children, and it manifests as a hypersensitivity reaction to the allergenic proteins in cow milk. Cow milk contains about 20 distinct protein components. The primary allergens are casein protein (alpha-s1-, alpha-s2-, beta-, and kappa-casein) and whey protein (alpha-lactalbumin and beta-lactoglobulin). There are several allergy treatments available, but they are just temporary. Developing a vaccine against milk allergy may appear utopian. Epitopes were found and exploited to build a multiprotein vaccine in this immunoinformatics study. Immunoinformatics techniques were used to predict T- and B-cell epitopes. Adjuvants were used to boost the vaccine’s antigenicity. The created vaccine design was shown to be soluble, antigenic, non-allergenic, and non-toxic.
Cow milk contains around 20 proteins which may cause allergy.
Immunoinformatics approach is used to design vaccine.
Allergens are identified and vaccine is constructed and tested
Allergy, Epitopes, Immunoinformatics, Milk proteins, Vaccine
