Effect of T. indica and T. arjuna on hematological parameters in rats exposed to fluoride

Excessive fluoride intake is found toxic to the body. It is a highly soluble salt, ubiquitously present in water and its contamination in drinking water poses a public health problem, needs immediate attention. Since oxidative damage is the main cause of fluoride toxicity, the antioxidant potential of tamarind and arjuna having many anti-oxidant phyto-chemicals, may be exploited for the amelioration of its toxicity. This study aims to evaluate the renoprotective effect of Tamarindus indica and Terminalia arjuna on hematology in rats exposed to sodium fluoride. The experimental groups included: (I) control, (II) NaF (100ppm in drinking water for 56 days), (III) NaF@ 100 ppm and extract of T. indica @ 200 mg/kg b.w. orally for 56 days, (IV) NaF @ 100 ppm and T. arjuna extract @50 mg/kg b.w. orally, (V) NaF @ 100 ppm, extract of Tamarindus indica @ 100 mg/kg b.w. orally and T. arjuna @ 25 mg/kg b.w. orally for 56 days, (VI) Ascorbic acid @ 100 mg/kg b.w. orally and NaF@ 100 ppm for 56 days. Blood samples were collected at different intervals. Haemoglobin, total leucocyte count, differential leucocyte count and total erythrocyte count were estimated. Compared to the control group, the fluoride-treated group showed significant differences in hematological parameter, including decrease in lymphocyte percentage. The group that received ascorbic acid showed significant increase in the lymphocyte percentage of the fluoride-exposed rats when compared to group II. The rats treated with T. indica and T. arjuna, separately and in combination, showed a numerical increase in lymphocyte percentage when compared to group II.

⓿ We studied the impact of fluoride induced nephrotoxicity in albino rats.

⓿ We investigated the effects of Tamarindus indica and Terminalia arjuna, individually and in combination, on fluoride-induced nephrotoxicity in albino rats.