1College of Animal Biotechnology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India
2Department of Veterinary Microbiology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India
3Department of Animal Biotechnology, Sher-e-Kashmir University of Agricultural Sciences and Technology, Shuhama Ganderbal, Srinagar, Jammu and Kashmir, India
4Department of Veterinary Microbiology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India
*Corresponding author: S Kour; E-mail: sanmeetkour131@gmail.com
Microbes are no longer viewed solely as vicious pathogens; they are recognized as pivotal players in human and animal health. The innate ability of microbes to interact with host systems provides a unique platform for the delivery of therapeutics via genetic engineering. “Designer” or bioengineered microbes represent a breakthrough for treating challenging chronic diseases such as cancer and addressing the alarming rise in antibiotic-resistant pathogens. These living therapeutics can be programmed to produce hormones, enzymes, antigens, and vitamins at the site of disease. As safety concerns regarding recombinant DNA persist, the development of sophisticated biocontainment devices offers a path forward. This review explores the architecture, applications, and challenges of bioengineered microbes as a judicious alternative to traditional antibiotics.
⓿ Bioengineered microbes have therapeutic potential.
⓿ There are challenges of bioengineered microbes as a judicious alternative to traditional antibiotics
Bioengineered microbes, Biocontainment, Therapeutics, Genetic Engineering
