1Division of Veterinary Pharmacology and Toxicology, F.V. Sc. and A.H., SKUAST-J, Jammu and Kashmir, India
2Division of Veterinary Anatomy, F.V. Sc. and A.H., SKUAST-J, Jammu and Kashmir, India
*Corresponding author: Y Dar; Email: yousufdar8@gmail.com
Online published on 29 January, 2016.
In the present study, haematological alterations induced by intraperitoneal administration of amikacin and the effect of aminoguanidine-hemisulphate alone and their combination was studied in wistar rats of either sex. Twenty-four healthy wistar rats divided into 4 groups (I, II, IIIand IV) were taken for the study. The intra-peritoneal administration of amikacinat at a dose rate of 15 mg/kg body weight for 28 days (Group-II) caused a significant decrease in haematological parameters like Hb, PCV, TEC and TLC as compared to control-group. Although a significant increase in parameters was found in aminoguanidine treated-rats on day 15th and 29th as compared to day zero within same group. However after the co-administration of amikacin and aminoguanidine, a non-significant change was found in same parameters (Hb, TEC, PCV and TLC) as compared to control.
Amikicin, aminoguanidine-hemisulphate, haematological alterations, wistar rats
