Evaluation of Biochemical Profile Alterations and Oxidative Stress in Mice Model on Oral Exposure to Deltamethrin

Present study was conducted to observe the biochemical alterations as well as oxidative stress in swiss albino male mice on exposure to low dose of deltamethrin through oral route for 15, 30 and 60 days. Three doses of deltamethrin viz., 0.5 mg/kg bwt/day, 1 mg/kg bwt/day and 1.5 mg/kg bwt/day dissolved in groundnut oil were administered orally. Control group was administered groundnut oil alone. Results indicate that the serum concentrations of aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN) and creatinine increased significantly (P < 0.05) on exposure to all the doses of deltamethrin as compared to control groups whereas TP and albumin decreased significantly indicating hepatic and kidney dysfunction. It was observed that deltamethrin causes severe oxidative stress to mice as observed by measuring the level of malondialdehyde (MDA), a marker for analyzing peroxidation of the lipid in the cells. The levels of MDA as well as superoxide dismutase (SOD) were found to be significantly high in the treatment group at all doses and exposure periods as compared to the control group indicating the oxidative stress. Therefore, the present study indicates significant alterations in biochemical profile as well as oxidative stress in mice exposed to the pesticide.