Haemato-biochemical Changes Following Administration of Propofol in Combination with Buprenorphine in Atropinized Dogs

The aim of study to find out the effect on haematological and biochemical parameters following administration of propofol alone and in-combinaiton with buprenorphine. Propofol was given to effect in group I (control), whereas buprenorphine @ 0.015 mg/kg b.wt. was given as preanaesthetic before propofol “to effect” in dogs of group II. Atropine sulphate was injected I/M @ 0.04 mg/kg b.wt. 20 minutes prior to each treatment in both the groups. Hb, PCV and TEC showed a significant fall (P<0.05) at initial intervals of observation as compared to base line whereas, other haematological parameters were non-significantly variables at different intervals of observation in both the groups. A non significant alteration in the level of total serum protein, alkaline phosphatase activity, serum creatinine and blood urea nitrogen could be recorded at different observation periods either within the group or among the groups. There was significant increase in serum glucose level at 1hr in both treatment groups followed by a progressive decrease in its value which reached to pretreatment value within 24hrs. There was significant increase (P<0.05) in AST value at 1hr in group Iwhereas in group II, it could be recorded at hr 1 and 2 of observation. A significant elevation (P<0.05) in ALT value could be recorded in both groups of animals at hr1 and 2 of observation as compared to their respective baseline value. It is concluded that propofol alone and in combination with buprenorphine produced no deleterious effect on the vital organs, hence can be used safely in dogs.