Evaluation of Efficacy of Propylene Glycol in the Treatment of Subclinical Ketosis and its effect on Plasma Concentration of Various Metabolic Parameters

Sub clinical ketosis is the excessive production of ketone bodies in blood leading to reduced reproductive performances and decreased milk yield without showing any clinical sign of ketosis. Since a lot of metabolic parameters are affected during the subclinical ketosis, which are having their roles in normal functioning of the body. Therefore the study was conducted to check the effcacy of Propylene glycol (PG) which was given @ 200 ml per day orally for 5 days in the treatment of subclinical ketosis and to study its effect on various metabolic parameters. A signifcant decrease was noted in the mean plasma Beta Hydroxyl Butyric Acid (BHBA) and Non Esterifed Fatty Acid (NEFA) values, along with a signifcant increase in the mean plasma glucose, calcium and total plasma proteins levels after treatment. The mean plasma inorganic phosphorus levels were within the normal range. A non signifcant decrease was observed in the mean plasma copper and zinc levels, where as a increase was noted in iron levels from the late pregnancy upto the early lactation period. However, a increase was noted in the mean values of copper and zinc after treatment with PG. Marked improvement was recorded in the oxidative stress parameters after feeding of PG It was concluded from the present study that Propylene glycol (PG) was given @ 200 ml per day orally for 5 days results in decrease in plasma NEFA and BHBA levels, indicating its effectiveness for treatment of sub clinical ketosis.