Pharmacokinetic Study of Single Dose Intravenous Administration of Enrofloxacin in Barbari Goats

Pharmacokinetic studies of enrofloxacin were performed after single intravenous (IV) administrations of 5 mg/kg body weight (BW) to 6 healthy Barbari goats. The study was performed by cross-over design. Blood samples were collected from jugular vein at predetermined time intervals after drug administration. Plasma enrofloxacin concentrations were measured by high performance liquid chromatography. Various pharmacokinetic parameters were calculated using non-compartmental model. The drug showed distribution half life (t_1/2α) of 0.11±0.02 h and elimination half life (t_1/2β) of 1.34±0.06 h. Large volume of distribution (Vd_area) of 3289.92±278 ml.kg⁻¹ in goats indicated high distribution of drug into various body fluids and tissues. The average values for area under plasma drug concentration-time curve AUC_(0-∞) and area under first moment curve (AUMC) was 2.97±0.19 μg.ml⁻¹.h and 5.03±1.41 μg.ml⁻¹.h², with mean residence time (MRT) of 1.68±0.24 h respectively.