1Department of TB and Respiratory Diseases, Institute of Medical Sciences, Banaras Hindu University, Varanasi (India)
2Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi (India)
3Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi (India)
4Division of Biostatistics, Institute of Medical Sciences, Banaras Hindu University, Varanasi (India)
Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity reaction to
To evaluate the clinical, immunological, microbiological and radiological features of
50 Patients with Bronchial Asthma as cases and 20 age and sex matched non asthmatic individuals as controls were selected for study from OPD of Department of TB and Respiratory Diseases, University Hospital, Institute of Medical Sciences, Banaras Hindu University, Varanasi during the period of January 2013 to July 2014. Various clinical, immunological, microbiological and radiological features of aspergillus infection in patients were recorded. The observed data was analyzed and intergroup comparisons were done.
In patients of bronchial asthma with positive aspergillus the percentage of presence of breathlessness, cough, family history, allergic rhinitis, history of ATT intake, AEC, IgE, IgG, BAL and CECT Thorax lied between 62.5% to 100% and most of these showed statistically significant difference.
The development of ABPAis probably the combination of many genetic susceptibility factors. Understanding of the genetic risks and immunopathogenesis of ABPA will lead to early diagnosis and improved treatment of ABPA.
Aspergillus, Aspergillosis, Bronchopulmonary Aspergillosis(ABPA), Bronchial Asthma
