1Ex resident, Dept of Ophthalmology, IMS, BHU
2Asst. professor, Dept of Genetics, IMS, BHU
3Professor, Dept of Ophthalmology, IMS, BHU
4Professor & Director, Regional Institute of Ophthalmology, Allahabad
5Ex Asst. Professor, Dept of Ophthalmology, IMS, BHU
To investigate the role of the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism in a large cohort of patients with POAG.
genetic analysis of 80 patients of POAG and 80 controls was done for MTHFR 677C>T polymorphism using PCR.
The C677T genotype is found to be very significantly associated with POAG) as compared to the controls. There is a significant difference in the frequency of distribution of genotype. The homozygous mutant genotype (TT) is also 1.25% more in cases as compared to controls.
There is significant association of MTHFR 677C>T polymorphism with POAG.
Glaucoma, Intraocular pressure, Primary open angle glaucoma
