Measurement of intracameral concentration of moxifloxacin achieved after topical application of the drug

To estimate Intracameral concentration of Moxifloxacin applied topically in different schedule.

Measurement of moxifloxacin was done in Aqueous aspirated before cataract extraction of different patients instilling topical drug in different schedule.

Significant difference was found between drug concentration of two groups, one instilling single drop of drug 30 min before surgery(1.20 ± 0.43 μg/ml) and other, instilling 4 drops a day before and one drop on day of surgery (1.80 ± 0.34 μg/ml).

Instilling moxifloxacin drops 1 day before cataract surgery results in higher concentration and is effective in endophthalmitis prevention.