Computational Studies on Carbon Distribution in Enzymes Involved in Neural Disorder

Carbon is only element that contributes towards the hydrophobic interactions in proteins. The hydrophobic interactions are the dominant force that determines the biomolecular association. The amount and distribution of carbon along the protein sequences particularly in enzyme are important factors that are not yet exploited very well. In order to capture these phenomena we have developed a computational method to identify the carbon distribution in a protein sequence. This newly developed method is applied to several proteins earlier. It is extended here to many enzymes that are involved in synthesis of neurologically important molecules. Enzymes such as tyrosine hydroxylase, tryptophan hydroxylase and aromatic amino acid decarboxylase of human and other animals are taken into account. The carbon distribution along these enzymes is studied and presented here. The method is able to identify the active sites (Carbon rich portion) that are same in different species but differs in amino acid sequence. The carbon distribution profile of these three enzymes in human and other species is presented and discussed.