Journal of Computational Intelligence in Bioinformatics

  • Year: 2009
  • Volume: 2
  • Issue: 1and2

Metabolism, Pharmacokinetics and Bioavailability of Ascorbic Acid; Synergistic Effect with Tocopherols and Curcumin

  • Author:
  • Jyoti Upadhyaya, Rajesh K. Kesharwani, Krishna Misra
  • Total Page Count: 8
  • DOI:
  • Page Number: 77 to 84

Indian Institute of Information Technology, Jhalwa, Allahabad - 211012.

Abstract

Pharmacokinetic study reveals absorption of ascorbic acid by two sodium-dependent vitamin C transporters, SVCT1 and SVCT2, one of which is encoded by the human gene SLC23A1. Bioavailability of vitamin C enhances remarkably in presence of tocopherols (vitamin E) and the turmeric component curcumin. In silico studies have been carried out to decipher the mechanism of pharmacokinetics/pharmacodynamics and bioavailability of vitamin C, by comparative protein modeling study of SLC23A1 using Modeler version 9v4 and Rampage server and flexible docking study using Molegro Virtual Docker software.

Keywords

Homology Modeling, MoleDock Scores, vitamin C, Modeller, RAMPAGE, ConSurf