Sjogren's Syndrome is an autoimmune disorder that attacks the body's moisture-producing glands, leading to progressively worsening dry mouth, eyes, vagina and skin, as well as fatigue. The syndrome boosts rheumatic disorders.
The mannose binding lectin (MBL) mutation protein is one of the cause for Sjogren's syndrome. A 3D structure of the MBL protein was modeled. Pernin (glycosylated protein) extracted from green lipped mussel is found to have anti-inflammatory property. Its 3D structure was modeled.
The active component of ayurvedic herbs turmeric and licorice is found to have anti-inflammatory activity. Their structure was sketched using ACD/Chemsketch, combined and converted to *.pdb. This combination is docked with pernin protein.
Again, the above combination is successfully docked with MBL protein which proves that the combination is effective in treating sjogren's syndrome.
Sjogren's Syndrome, Autoimmune disorder, Rheumatic disorders, Bioinformatics, Mannose binding lectin, Ayurvedic herbs, Pernin, Homology modelling, Docking
