Journal of Camel Practice and Research
SCOPUS
  • Year: 2016
  • Volume: 23
  • Issue: 1

Molecular mechanism of hepato-renal protection of camel milk against oxidative stress-perturbations

  • Author:
  • Zein Shaban Ibrahim1,4, Mohamed Alkafafy2,5, Mohamed Mohamed Soliman3,6, Mohamed Mohamed Ahmed2,7
  • Total Page Count: 11
  • Page Number: 53 to 63

1Department of Physiology, College of Science, Taif University, Turabah, Saudi Arabia

2Department of Biotechnology, Faculty of Medicine, College of Science, Taif University, Turabah, Saudi Arabia

3Medical Laboratories Department College of Applied Medical Sciences, Taif University, Turabah, Saudi Arabia

4Department of Physiology, Faculty of Veterinary Medicine, Kaferelsheikh University, Egypt

5Department of Histology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Egypt

6Department of Biochemistry, Benha University, Moshtohor, Egypt

7Department of biochemistry, College of Veterinary Medicine, University of Sadat City, Egypt

Online published on 26 August, 2016.

Abstract

Possible molecular mechanism of camel milk protection of liver and kidney against oxidative stress generated by CCl4 injection was investigated. Rats injected with carbon tetrachloride (CCl4) showed upregulation of the mRNA expression of hepatic IL-6 and renal IL-1β, TGF- β1, SREBP-1c and caspase-6 and down-regulation of anti-oxidative enzymes SOD, GST and CAT in addition to hepatocellular vacuolation, mononuclear cell infiltration and sinusoidal dilatation and renal glomerular atrophy, capsular space expansion, and adhesion between visceral and parietal layers of Bowman's capsule. Camel milk supplementation prior and with CCl4 injection to rats attenuated CCl4-induced hepatic and renal inflammatory cytokines (IL-6, IL-1β, TGF- β1 SREBP-1c and caspase-6), upregulated CCl4-suppressed anti-oxidative markers (SOD, GST and CAT) and induced protective and regenerative mechanism (EPO and IL-10). Additionally camel milk protected the liver and kidney from CCl4-induced histopathological changes. These results showed the mechanism of camel milk protection of liver and kidney against CCl4-generated oxidative stress and injuries. These findings may support the beneficial use of camel milk as therapeutic adjuvant with drugs that always associated with production of oxidative stress that injured liver and kidneys as anti-tumor drugs as Cisplatin.

Keywords

Camel, hepato-renal protection, milk, oxidative stress