Journal of Camel Practice and Research
SCOPUS
  • Year: 2020
  • Volume: 27
  • Issue: 3

Transcriptome alterations in high glucose-induced renal tubular cells of bactrian camel

  • Author:
  • Bin Yang1,¶, Lihui Chen1,¶, Xin Li2, Zhuwei Guo1, Shi Liu3, Demtu Er,1
  • Total Page Count: 4
  • Published Online: Jan 11, 2021
  • Page Number: 301 to 304

1College of Veterinary Medicine, Inner Mongolia Agricultural University, Key Laboratory of Clinical Diagnosis and Treatment Technology in Animal Disease, Ministry of Agriculture, Ministry of Agriculture and Rural Affairs of P. R. China, Hohhot, Inner Mongolia Autonomous Region, 010011, China

2Animal disease prevention and control centre of Urad Back Banner, Bayannur city, 015543, Inner Mongolia Autonomous Region, P. R. China

3Animal disease prevention and control centre of Alxa Left Banner, Bayanhot, 750300, Inner Mongolia Autonomous Region, P. R. China

 SEND REPRINT REQUEST TO CORRESPONDING AUTHOR DEMTU ER* email: eedmt@imau.edu.cn

Co-first author: Bin Yang¶ and Lihui Chen

Abstract

The transcriptome alterations in renal tubular cells of Bactrian camel treated with high glucose were investigated. Primary tubular epithelial cells, obtained from kidney of Bactrian camel were treated with low glucose (LG) or high glucose (HG). The transcriptome gene expression in primary tubular epithelial cells of Bactrian camel was examined using RNA sequencing technology. 1322 genes from HG and LG were significantly altered. The up- regulated genes in the HG group include CAMK2B, CRYAA and VNN1. Several pathways associated with diabetic nephropathy including PI3K-Akt signaling pathway, AGE-RAGE signaling pathway, ECM-receptor interaction and PPAR signaling pathway were activated by HG stimulation. This study provides scientific basis for understanding the mechanism of renal tolerance to hyperglycemia of Bactrian camel.

Keywords

Bactrian camel, High glucose, Transcriptome, Tubular epithelial cells