Protective effects of urine and milk of camel on isoniazid and rifampicin induced hepatotoxicity

The objective of the present study was to study the hepatoprotective effects of camel milk and urine in 5 groups of 8 rabbits. The first group I received saline solution (control), animals in group 2 received daily isoniazid (50 mg/Kg/d) with rifampicin (100 mg/Kg/d) orally during 10 days. Rabbits in groups 3, 4, 5 received isoniazid (50 mg/kg/day) and rifampicin (100 mg/kg/d) with added milk, urine, and a mixture of camel milk and urine, respectively. Camel milk was administered @ 33 ml, kg bodyweight, day with oral gavage using a nasopharyngeal catheter. Urine was administered @ 20 ml, kg bodyweight, day. Plasma levels of bilirubin, and activities of ALAT, ASAT and PAL were measured. Histological variations on liver tissues were also described. Group 2 rabbits showed a non-significant increase in plasma ALAT and ASAT levels and a very significant increase in bilirubin and PAL. Histological sections of liver of rabbits in group 2 showed signs of hepatocyte suffering, these biochemical changes were reversed in groups 3, 4 and 5 animals compared to the group 2. Histological variations were also reduced in animals receiving camel milk and urine mixture. Camel milk and urine thus have protective effects on hepatotoxicity induced by isoniazid-Rifampicin combination.