Journal of Camel Practice and Research
SCOPUS
  • Year: 2023
  • Volume: 30
  • Issue: 2

Studies on Cytotoxic Activity of Camel Milk Whey Protein as a Nutraceutical against HeLa Cells

  • Author:
  • Manohar Lal1, Neelam Mahala1,2, Aastha Mittal1, Anisha Ramdas1, Chetan Shrivastava1, Uma S. Dubey1,*
  • Total Page Count: 10
  • Published Online: Aug 16, 2023
  • Page Number: 155 to 164

1Department of Biological Sciences, Birla Institute of Technology of Science, Pilani (BITS, Pilani), Pilani Campus, Rajasthan-333031, India

2Department of Biotechnology, Parul Institute of Technology, Parul University, Vadodara, Gujarat-391760, India

*SEND REPRINT REQUEST TO UMA S. DUBEY email: uma@pilani.bits-pilani.ac.in

Online Published on 16 August, 2023.

Abstract

The present study was based on cytotoxic properties of camel milk and its whey against the cervical cancer-derived cell line, HeLa. High concentrations of camel milk and whey were cytotoxic against these cells. Camel milk whey inhibited the migration of these transformed cells, increased the activity of caspase 3, fragmented DNA by PCD, and regulated the CYP1A1 oncogene at the transcriptional level. Thus, camel milk whey can be considered as a potent nutraceutical with anti-cancer property.

Keywords

Camel milk, Casein, Caspase, Cytotoxicity, HeLa cells, Nutraceutical, Protein, Whey