1Department of Complementary Medicine, European Board, Iraq
2Agriculture College, Al Muthanna University, Iraq
3Environment Research Center, University of Technology-Iraq, Baghdad, Iraq
4Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq
5Department of Studies and Planning, University of Technology-Iraq, Baghdad, Iraq
6Biology Department, Faculty of Science and Mathematics, Sultan Idris Education University, Perak, 35900, Malaysia
7Ibn Al_Betar Research Center, Corporation of Research and Industrial Development, Ministry of Industry and Minerals, Baghdad, Iraq
*Corresponding Author: M.T.A. Mohammed, Environment Research Center, University of Technology-Iraq, Baghdad, Iraq, Email: mohammed.m.ta@uotechnology.edu.iq
Online Published on 06 January, 2024.
Cancer is still a major health problem worldwide, despite the big development in treatment and diagnostic methods. For this reason, this study aims to find new drugs with low cost and fewer side effects on cancer cells continue. Medical plants represent a suitable candidate for discovering new materials for cancer treatment.
Ten plants usually used in traditional medicine were used to evaluate their effectiveness as anti-cancer. These plants were divided into two mixtures according to traditional usage, named mixtures A and B. The anticancer effect against HepG2 was determined by MTT assay. The IC50 was also calculated.
Mixture A showed cytotoxicity reached 66.98%, while mixture B showed 63.66% by using 400 µg/ml at 48 h. The IC50 for mixture A was 53 µg/ml, while for mixture B was 44.29 g/ml. All these results compare to normal cell line HnFd cells. In conclusion, mixing medical plants can effectively increase the anticancer activity of the synergistic effect between the phytochemicals. Future studies will be done to scan these effects.
Anticancer activity, Cancer, Cytotoxicity, Medicinal plants, Phytochemicals
